The Effect Long Time Suplementation of Ferrous Sulphate to Blood Glucose Levels In Pregnant Rats

Siti Fadhilah, Mustika Pramestiyani

Abstract


 

Iron supplements and an increase in reserves of iron in the blood was associated with complications in pregnant women because of an increase in oxidative during stress. The purpose of this research is to knowing blood sugar levels while on pregnant rats (Rattus novergicus) which given ferro sulfate with different length of time. This research was design as an experimental research design as post test only control group design. The sample that used was  24 rats strain wistar  which divided into 1 control group (no exposure) and 3 treatment groups (granting of ferro sulfate dosage 60mg/day through the sonde for 20 days, 14 days and 6 days). The analysis of data was using Anova  One way test. The result of Kruskal Wallis test on  acquired GDS levels got any meaningful differences of average levels of  four  GDS  sample  observation group (p-value=0.001). The LSD test results showed there was any meaningful difference of GDS average level between control group (150.67±31.07a)  with granting treatment group of ferro sulfate during 20 (P1=215.33±22.9b), 14 days (P2 = 191.50 8.11 ± c) and 6 days (P3 = 155.5 ± 18:59 d). The conclusion of this study is as short as granting time of ferro sulfat can decreased the GDS level in pregnant rats.


Keywords


Ferruso Sulphate; blood glucose level

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References


Andrews, N. C., & Schmidt, P. J. (2007). Iron Homeostasis. Annual Review of Physiology, 69(1), 69–85. https://doi.org/10.1146/annurev.physiol.69.031905.164337

Arnaud, J., Roussel, A.-M., Favier, A., Faure, H., Hininger, I., Lachili, B., & Richard, M.-J. (2003). Increased Lipid Peroxidation in Pregnant Women after Iron and Vitamin C Supplementation. Biological Trace Element Research, 83(2), 103–110. https://doi.org/10.1385/bter:83:2:103

Bothwell, T. H. (2000). Iron requirements in pregnancy and strategies to meet them. American Journal of Clinical Nutrition, 72(1 SUPPL.). https://doi.org/10.1093/ajcn/72.1.257S

Gambling, L., Czopek, A., Andersen, H. S., Holtrop, G., Srai, S. K. S., Krejpcio, Z., & Mcardle, H. J. (2009). Fetal iron status regulates maternal iron metabolism during pregnancy in the rat. 1063–1070. https://doi.org/10.1152/ajpregu.90793.2008.

González-Sarrías, A., García-Villalba, R., Núñez-Sánchez, M. Á., Tomé-Carneiro, J., Zafrilla, P., Mulero, J., … Espín, J. C. (2015). Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts. Journal of Functional Foods, 19, 225–235. https://doi.org/10.1016/j.jff.2015.09.019

Kemenkes R1. 2014. Peraturan Menteri Kesehatan Republik Indonesia Nomor 88 Tahun 2014 Tentang Standar Tablet Tambah Darah Bagi Wanita Usia Subur Dan Ibu Hamil. Jakarta : Kemenkes RI

P., J., S., A., M.H., G., & S., H. (2014). Gestational diabetes mellitus and iron supplement; effects on pregnancy outcome. Acta Medica Iranica, 52(5), 385–389. Retrieved from http://acta.tums.ac.ir/index.php/acta/article/view/2067/4635%255Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed12&NEWS=N&AN=2014372518

Salmenhaara, M., Uusitalo, L., Uusitalo, U., Kronberg-Kippilä, C., Sinkko, H., Ahonen, S., … Virtanen, S. M. (2010). Diet and weight gain characteristics of pregnant women with gestational diabetes. European Journal of Clinical Nutrition, 64(12), 1433–1440. https://doi.org/10.1038/ejcn.2010.167

Scholl, T. O. (2005). Iron status during pregnancy : setting the stage for mother and IRON DEFICIENCY IN WOMEN. American Journal of Clinical Nutrition, 81, 1218–1223.

Sharp, P. (2015). Molecular mechanisms involved in intestinal iron absorption. World Journal of Gastroenterology, 13(35), 4716. https://doi.org/10.3748/wjg.v13.i35.4716

Zein, S., Rachidi, S., Awada, S., Osman, M., Al-hajje, A., Shami, N., … Hininger-favier, I. (2015). Journal of Trace Elements in Medicine and Biology High iron level in early pregnancy increased glucose intolerance. Journal of Trace Elements in Medicine and Biology, 30, 220–225. https://doi.org/10.1016/j.jtemb.2014.09.004

Zhuang, T., Han, H., & Yang, Z. (2014). Iron, oxidative stress and gestational diabetes. Nutrients, 6(9), 3968–3980. https://doi.org/10.3390/nu6093968




DOI: https://doi.org/10.30736/md.v12i1.176

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